The incoming EU Whistleblowing Directive 2019 will require many organizations* to make significant changes to protect whistleblowers against retaliation, establish confidential whistleblower channels and clear reporting processes. Organisations must implement arrangements now that enable employees to speak up about perceived wrongdoing. But how to go about this? This research examined key organizations in the finance, health, engineering and public sectors in several countries. Opportunities, challenges, common mistakes and best practices were studied, across different types of speak-up arrangements. The research was supported by the Association of Chartered Certified Accountants (ACCA) and the Economic and Social Research Council (ESRC).